Oral-Systemic Interactions and Medical-Dental Integration: A Life Course Approach, a 2023 report from the CareQuest Institute for Oral Health, discusses the need to understand a life course approach regarding both oral-systemic interactions (OSI) and medical-dental integration (MDI). It provides a comprehensive overview of the bidirectional nature of oral and systemic diseases across different life phases and how health care delivery in an integrated form can improve access to care and health outcomes. Finally, it discusses the gaps, challenges, and barriers to creating integrated models, and provides recommendations to improve the future of MDI.